Beilstein J. Org. Chem.2010,6, 742–747, doi:10.3762/bjoc.6.93
thiolatednucleoside to obtain the hybrid model compound.
Keywords: adenylosuccinate synthetase (AdSS); thiolatednucleoside; Introduction
During cell proliferation, adenine nucleotides for nucleic acid synthesis are generated through a de novo biosynthetic route, which requires the key enzyme
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Graphical Abstract
Figure 1:
Structure of AdSS catalytic domain from Mg center (light blue) to IMP loop (tan) with compound 13 d...